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For this pick-upfront bracket contest, the deadline to make picks was 12:15 PM EDT on March 19th.
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| Louisville | Louisville | Louisville | Louisville | | Ohio State | Siena | Ohio State | Siena | | Utah | Arizona | Utah | Arizona | | Wake Forest | Wake Forest | Wake Forest | Wake Forest | | W. Virginia | Dayton | W. Virginia | W. Virginia | | Kansas | Kansas | Kansas | Kansas | | USC | Boston College | Boston College | USC | | Michigan St | Michigan St | Michigan St | Michigan St | |
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| Pittsburgh | Pittsburgh | Pittsburgh | Pittsburgh | | Tennessee | Oklahoma St | Tennessee | Oklahoma St | | Wisconsin | Florida St | Florida St | Wisconsin | | Xavier | Xavier | Xavier | Xavier | | VCU | VCU | UCLA | UCLA | | Villanova | Villanova | Villanova | Villanova | | Texas | Minnesota | Texas | Texas | | Duke | Duke | Duke | Duke | |
| N. Carolina | N. Carolina | N. Carolina | N. Carolina | | Butler | Butler | LSU | LSU | | W Kentucky | W Kentucky | Illinois | Illinois | | Gonzaga | Gonzaga | Gonzaga | Gonzaga | | Arizona St | Arizona St | Arizona St | Temple | | Syracuse | Syracuse | Syracuse | Syracuse | | Michigan | Michigan | Clemson | Michigan | | Oklahoma | Oklahoma | Oklahoma | Oklahoma | |
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| Louisville | Louisville | Louisville | Louisville | | Wake Forest | Wake Forest | Wake Forest | Wake Forest | | W. Virginia | Kansas | Kansas | Kansas | | Michigan St | Michigan St | Michigan St | Michigan St | |
| Connecticut | Connecticut | Connecticut | Connecticut | | Purdue | Purdue | Washington | Purdue | | Missouri | Marquette | Missouri | Cornell | | Memphis | Memphis | Memphis | Memphis | |
| Pittsburgh | Pittsburgh | Tennessee | Pittsburgh | | Xavier | Florida St | Florida St | Xavier | | Villanova | Villanova | Villanova | Villanova | | Duke | Duke | Duke | Duke | |
| N. Carolina | N. Carolina | N. Carolina | N. Carolina | | Gonzaga | Gonzaga | Gonzaga | Gonzaga | | Syracuse | Syracuse | Syracuse | Syracuse | | Oklahoma | Oklahoma | Oklahoma | Oklahoma | |
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| Louisville | Louisville | Louisville | Louisville | | Michigan St | Kansas | Michigan St | Michigan St | |
| Purdue | Connecticut | Connecticut | Connecticut | | Missouri | Memphis | Memphis | Memphis | |
| Pittsburgh | Pittsburgh | Tennessee | Pittsburgh | | Duke | Villanova | Duke | Duke | |
| N. Carolina | N. Carolina | N. Carolina | N. Carolina | | Oklahoma | Syracuse | Oklahoma | Syracuse | |
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| Louisville | Louisville | Louisville | Louisville | |
| Missouri | Memphis | Memphis | Memphis | |
| Pittsburgh | Pittsburgh | Duke | Duke | |
| Oklahoma | N. Carolina | N. Carolina | N. Carolina | |
| Louisville | Louisville | Louisville | Memphis | | Pittsburgh | Pittsburgh | N. Carolina | N. Carolina | |
| Pittsburgh | Louisville | Louisville | Memphis |
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